Takaki M, Jin J G, Nakayama S
Department of Physiology, Okayama University Medical School, Shikatacho, Japan.
Eur J Pharmacol. 1989 Dec 12;174(1):57-62. doi: 10.1016/0014-2999(89)90873-x.
Ruthenium red (1 microM), an inorganic dye which blocks transmembrane calcium (Ca) fluxes in neural tissues, selectively reduced the capsaicin (1 microM)-induced contraction of the guinea-pig ileum and protected the sensory fibers from capsaicin-induced desensitization. The ruthenium red (0.5-1 microM) antagonism of capsaicin-induced inhibition of responses to mesenteric nerve stimulation or field stimulation in the isolated guinea-pig ileum was an example of a similar antagonism of the effect of capsaicin. In view of the known action of ruthenium red on the depolarization-coupled entry of Ca into synaptosomes and the release of transmitter, our results support the proposal that ruthenium red could antagonize the action of capsaicin on the peripheral terminals of sensory nerves by a similar mechanism, thereby suppressing transmitter release and preventing the establishment of desensitization.
钌红（1微摩尔）是一种无机染料，可阻断神经组织中的跨膜钙（Ca）通量，它能选择性地减轻辣椒素（1微摩尔）诱导的豚鼠回肠收缩，并保护感觉纤维免受辣椒素诱导的脱敏作用。钌红（0.5 - 1微摩尔）对辣椒素诱导的豚鼠离体回肠中肠系膜神经刺激或场刺激反应抑制的拮抗作用，是辣椒素作用类似拮抗作用的一个例子。鉴于钌红对Ca进入突触体的去极化偶联进入及递质释放的已知作用，我们的结果支持这样的观点，即钌红可能通过类似机制拮抗辣椒素对感觉神经外周终末的作用，从而抑制递质释放并防止脱敏的建立。
