Suner Ali, Buyukhatipoglu Hakan, Balakan Ozan, Kalender Mehmet Emin, Ulas Turgay, Sevinc Alper, Camci Celalettin
Department of Medical Oncology, School of Medicine, Gaziantep University, Kilis Yolu Uzeri, 27310 Gaziantep, Turkey.
Depatment of Internal Medicine, Harran University School of Medicine, Sanliurfa, Turkey.
Case Rep Oncol Med. 2014;2014:731581. doi: 10.1155/2014/731581. Epub 2014 Apr 13.
Gastric cancer is one of most common types of cancers. Metastatic gastric cancer has a poor prognosis and is accepted as incurable at this stage. Treatment of metastatic gastric cancer did not progress substantially until new targeted agents have come out. Recently published ToGA trial showed promising results in HER2 overexpressing metastatic gastric cancer. In this case we present a case with an excellent complete response with anti-HER2 treatment. Most importantly, we wanted to emphasize (1) the importance of early determination of HER2 overexpression, and (2) to draw attention of anti-HER2 agents in the first line treatment even in patients with a poor performance status.
胃癌是最常见的癌症类型之一。转移性胃癌预后较差，目前被认为在这个阶段无法治愈。直到新型靶向药物出现，转移性胃癌的治疗才取得实质性进展。最近发表的ToGA试验显示，在HER2过表达的转移性胃癌中取得了有前景的结果。在本病例中，我们展示了一例接受抗HER2治疗后获得极佳完全缓解的病例。最重要的是，我们想强调：（1）早期确定HER2过表达的重要性；（2）即使是身体状况较差的患者，在一线治疗中也应关注抗HER2药物。
