Abbas Ozan L, Borman Huseyin, Bahar Taner, Ertaş Nilgün M, Haberal Mehmet
From the *Department of Plastic and Reconstructive Surgery, Ahi Evran University, Kırşehir, Turkey; and Departments of †Plastic and Reconstructive Surgery and ‡General Surgery, Baskent University, Ankara, Turkey.
J Burn Care Res. 2015 Mar-Apr;36(2):e47-54. doi: 10.1097/BCR.0000000000000072.
Topical antimicrobials are frequently used for local control of infections in burn patients. It has been postulated that these agents retard wound healing. There are limited data about the effects of topical antimicrobial agents on skin graft healing. In this study, we aimed to evaluate the effects of nitrofurazone, 1% silver sulfadiazine, and povidone-iodine on skin graft healing. Forty male rats were used in this study. A meshed skin graft, placed on an excised burn wound, was used as a model to compare topical agents with a control group. Skin graft survival rates, closure of meshed graft interstices (based on physical parameters, namely epithelialization and wound contraction), and histological changes were analyzed. Graft take was more than 85% in all groups. There was no difference between the mean values of the percent graft survival for each group (P > .05). Epithelialization occurred significantly earlier in animals in the nitrofurazone group (P < .05). There was no significant difference between groups in wound contraction rates (P >.05). There was no histological difference between the biopsy specimens of skin grafts. In specimens obtained from the interstices of the meshed graft, no significant differences were found among the groups regarding the wound healing parameters (P > .05). We found that nitrofurazone, silver sulfadiazine, and povidone-iodine had no negative effect on graft healing and take in noncontaminated burn wounds.
局部抗菌剂常用于烧伤患者感染的局部控制。据推测，这些药物会延缓伤口愈合。关于局部抗菌剂对皮肤移植愈合影响的数据有限。在本研究中，我们旨在评估呋喃西林、1%磺胺嘧啶银和聚维酮碘对皮肤移植愈合的影响。本研究使用了40只雄性大鼠。将网状皮肤移植片置于切除的烧伤创面上，作为模型来比较局部用药组与对照组。分析了皮肤移植成活率、网状移植间隙的闭合情况（基于上皮化和伤口收缩等物理参数）以及组织学变化。所有组的移植成功率均超过85%。各组移植成活率百分比的平均值之间无差异（P>.05）。呋喃西林组动物的上皮化明显更早发生（P<.05）。各组间伤口收缩率无显著差异（P>.05）。皮肤移植活检标本之间无组织学差异。在从网状移植间隙获取的标本中，各组在伤口愈合参数方面无显著差异（P>.05）。我们发现，呋喃西林、磺胺嘧啶银和聚维酮碘对未受污染烧伤创面的移植愈合和成功率没有负面影响。
