Research, VA Medical Centre Sacramento; Department of Internal Medicine, Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis School of Medicine, Davis, CA 95616, USA.
Indian J Dermatol Venereol Leprol. 2014 May-Jun;80(3):204-13. doi: 10.4103/0378-6323.132247.
Psoriasis is a multifactorial chronic inflammatory disease. Research into the pathogenesis of this disease is hindered by the lack of a proper animal model. Over the past two decades, many scientists were involved in the development of animal models that nearly mirror the immunopathogenesis of psoriasis. One such model, which has opened doors to the study of molecular complexities of psoriasis as well as its treatment, is the severe combined immunodeficiency (SCID) mouse-human skin chimera model. This model not only mirrors the clinical and histopathological features of psoriasis but also help in the study of cell proliferation, angiogenesis, function of T cells, neurogenic inflammation and cytokines involved in inflammatory reactions. In this article, we have reviewed the prospects and the limitations of the SCID mouse model of psoriasis.
银屑病是一种多因素的慢性炎症性疾病。由于缺乏合适的动物模型，该疾病的发病机制研究受到阻碍。在过去的二十年中，许多科学家致力于开发能够模拟银屑病免疫发病机制的动物模型。其中一种模型，即严重联合免疫缺陷（SCID）小鼠-人皮肤嵌合体模型，为研究银屑病的分子复杂性及其治疗方法开辟了道路。该模型不仅能模拟银屑病的临床和组织病理学特征，还有助于研究细胞增殖、血管生成、T 细胞功能、神经源性炎症以及参与炎症反应的细胞因子。本文综述了 SCID 小鼠银屑病模型的前景和局限性。
