基于序列同源性的假基因注释计算方法。

Computational methods for pseudogene annotation based on sequence homology.

作者信息

Harrison Paul M

机构信息

Department of Biology, McGill University, Stewart Biology Building, 1205 Doctor Penfield Avenue, Montreal, QC, Canada, H3A 1B1,

出版信息

Methods Mol Biol. 2014;1167:27-39. doi: 10.1007/978-1-4939-0835-6_3.

DOI:10.1007/978-1-4939-0835-6_3

PMID:24823769

Abstract

The number of complete genome sequences explodes more and more with each passing year. Thus, methods for genome annotation need to be honed constantly to handle the deluge of information. Annotation of pseudogenes (i.e., gene copies that appear not to make a functional protein) in genomes is a persistent problem; here, we overview pseudogene annotation methods that are based on the detection of sequence homology in genomic DNA.

摘要

每年，完整基因组序列的数量都在不断激增。因此，基因组注释方法需要持续优化，以处理海量信息。基因组中假基因（即那些似乎无法产生功能性蛋白质的基因拷贝）的注释一直是个难题；在此，我们概述基于检测基因组DNA序列同源性的假基因注释方法。