Wagner R, Häring H-U, Fritsche A
Innere Medizin IV, Abteilung für Endokrinologie, Diabetologie, Vaskuläre Medizin, Nephrologie und Klinische Chemie, Universitätsklinikum Tübingen.
Dtsch Med Wochenschr. 2014 May;139(21):1109-13. doi: 10.1055/s-0034-1370076. Epub 2014 May 13.
Type 2 Diabetes is a heterogeneous disease which harbors several different pathomechanistic entities. For a successful prevention, it is important to understand the exact pathomechanisms. Overt type 2 Diabetes usually develops through an intermediary state called prediabetes, which is also heterogeneous. This state is especially important, because it already confers a higher risk for diabetes-associated complications. Therefore, detection of prediabetes and prevention of its progression to diabetes would be desirable. In this review, we describe the phenotypes of prediabetes and type 2 diabetes. We also try to envision the first steps of a future phenotype-oriented diabetes therapy.
2型糖尿病是一种异质性疾病，包含几种不同的病理机制实体。为了成功预防，了解确切的病理机制很重要。显性2型糖尿病通常通过一种称为糖尿病前期的中间状态发展而来，这种状态也是异质性的。这种状态尤为重要，因为它已经赋予了更高的糖尿病相关并发症风险。因此，检测糖尿病前期并预防其进展为糖尿病是可取的。在这篇综述中，我们描述了糖尿病前期和2型糖尿病的表型。我们还试图设想未来以表型为导向的糖尿病治疗的第一步。
