Song Jinhaeng, Jeon Ju-Eun, Won Tae Hyung, Sim Chung J, Oh Dong-Chan, Oh Ki-Bong, Shin Jongheon
Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea.
Department of Biological Science, College of Life Science and Nano Technology, Hannam University, 461-6 Jeonmin, Yuseong, Daejeon 305-811, Korea.
Mar Drugs. 2014 May 12;12(5):2760-70. doi: 10.3390/md12052760.
Two new peptides, chujamides A (1) and B (2), were isolated from the marine sponge Suberites waedoensis, which was collected from Korean waters. Based upon the results of the combined spectroscopic analyses, the structures of these compounds were determined to be proline-riched and cyclic cystine bridged dodeca- and undecapeptides. The absolute configurations of all amino acid residues were determined to be l by advanced Marfey's analysis. The new compounds exhibited weak cytotoxicities against A549 and K562 cell-lines, and compound 2 also demonstrated moderate inhibitory activity against Na⁺/K⁺-ATPase.
从采集自韩国海域的海洋海绵威岛软海绵（Suberites waedoensis）中分离出了两种新的肽，即初岛酰胺A（1）和B（2）。基于联合光谱分析的结果，确定这些化合物的结构为富含脯氨酸且具有环胱氨酸桥连的十二肽和十一肽。通过先进的马尔费方法分析确定所有氨基酸残基的绝对构型均为L型。新化合物对A549和K562细胞系表现出微弱的细胞毒性，化合物2对Na⁺/K⁺-ATP酶也表现出中等程度的抑制活性。
