芝麻油和芝麻素的镇痛和抗炎活性。
Antinociceptive and anti-inflammatory activities of the sesame oil and sesamin.
机构信息
Pharmaceutical Sciences Post-Graduation Program, Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais 36036-900, Brazil.
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais 36036-900, Brazil.
出版信息
Nutrients. 2014 May 12;6(5):1931-44. doi: 10.3390/nu6051931.
Sesame oil is widely consumed as nutritious food, cooking oil, and in pharmaceuticals and food. In this study, the antinociceptive and anti-inflammatory properties of the sesame oil and sesamin were investigated. The sesame oil and sesamin reduced the number of abdominal contortions at the doses 100, 200, or 400 mg/kg. The first and second phases of the time paw licking were inhibited by sesame oil and sesamin (100, 200, or 400 mg/kg). After 90 min of treatment, sesame oil and sesamin increased the reaction time on a hot plate (200 or 400 mg/kg). Considering the tail-immersion assay, the sesame oil and sesamin produced significant effect after 60 min at the doses of 100, 200, or 400 mg/kg. After 4 h of application of the carrageenan, the sesame oil and sesamin were effective against the paw edema. The exudate volume and leucocyte migration were also reduced by sesame oil and sesamin. These results suggest that sesamin is one of the active compounds found in sesame oil and justify the antinociceptive and anti-inflammatory properties of this product.
芝麻油作为营养食品、食用油以及在制药和食品中被广泛消费。在这项研究中，研究了芝麻油和芝麻素的镇痛和抗炎特性。芝麻油和芝麻素在 100、200 或 400 mg/kg 剂量下减少了腹部扭曲的次数。芝麻油和芝麻素（100、200 或 400 mg/kg）抑制了第一和第二阶段的舔足时间。治疗 90 分钟后，芝麻油和芝麻素增加了热板上的反应时间（200 或 400 mg/kg）。考虑到尾巴浸泡试验，在 100、200 或 400 mg/kg 剂量下，60 分钟后芝麻油和芝麻素产生了显著效果。在角叉菜胶应用 4 小时后，芝麻油和芝麻素对爪肿胀有效。芝麻油和芝麻素还减少了渗出物量和白细胞迁移。这些结果表明，芝麻素是芝麻油中发现的一种活性化合物，证明了该产品的镇痛和抗炎特性。
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