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Methylation of the hTERT promoter is frequent in choroid plexus tumors but not of independent prognostic value.

作者信息

Ruland Vincent, Hartung Stefan, Kordes Uwe, Wolff Johannes E, Paulus Werner, Hasselblatt Martin

机构信息

Institute of Neuropathology, University Hospital Münster, Pottkamp 2, 48149, Münster, Germany.

出版信息

J Neurooncol. 2014 Aug;119(1):215-6. doi: 10.1007/s11060-014-1473-7. Epub 2014 May 14.

DOI:10.1007/s11060-014-1473-7
PMID:24825541
Abstract
摘要

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Methylation of the hTERT promoter is frequent in choroid plexus tumors but not of independent prognostic value.端粒酶逆转录酶（hTERT）启动子甲基化在脉络丛肿瘤中很常见，但无独立的预后价值。
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Choroid plexus carcinomas are characterized by complex chromosomal alterations related to patient age and prognosis.脉络丛癌的特点是与患者年龄和预后相关的复杂染色体改变。
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Intron 4-5 hTERT DNA Hypermethylation in Merkel Cell Carcinoma: Frequency, Association with Other Clinico-pathological Features and Prognostic Relevance.

本文引用的文献

1
Choroid plexus carcinomas are characterized by complex chromosomal alterations related to patient age and prognosis.脉络丛癌的特点是与患者年龄和预后相关的复杂染色体改变。
Genes Chromosomes Cancer. 2014 May;53(5):373-80. doi: 10.1002/gcc.22148. Epub 2014 Jan 30.
2
Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study.TERT 启动子甲基化与儿童脑肿瘤的风险分层：一项综合基因组学和分子研究。
Lancet Oncol. 2013 May;14(6):534-42. doi: 10.1016/S1470-2045(13)70110-4. Epub 2013 Apr 16.
3
Atypical choroid plexus papilloma: clinical experience in the CPT-SIOP-2000 study.
默克尔细胞癌中内含子 4-5 hTERT DNA 超甲基化：频率、与其他临床病理特征的关系及预后相关性。
Endocr Pathol. 2021 Sep;32(3):385-395. doi: 10.1007/s12022-021-09669-y. Epub 2021 Apr 28.
4
Detection of Aberrant TERT Promoter Methylation by Combined Bisulfite Restriction Enzyme Analysis for Cancer Diagnosis.联合亚硫酸氢盐限制性内切酶分析法检测TERT启动子异常甲基化用于癌症诊断
J Mol Diagn. 2017 May;19(3):378-386. doi: 10.1016/j.jmoldx.2017.01.003. Epub 2017 Mar 9.
5
hTERT promoter methylation in meningiomas and central nervous hemangiopericytomas.脑膜瘤和中枢神经系统血管外皮细胞瘤中的人端粒酶逆转录酶启动子甲基化
J Neurooncol. 2016 Oct;130(1):79-87. doi: 10.1007/s11060-016-2226-6. Epub 2016 Jul 27.
非典型脉络丛乳头状瘤：CPT-SIOP-2000 研究中的临床经验。
J Neurooncol. 2009 Dec;95(3):383-392. doi: 10.1007/s11060-009-9936-y. Epub 2009 Jun 20.