[Kidney transplant rejection and the original kidney disease of the recipient].

Glomerulonephritis, pyelonephritis, diabetic nephropathy, and polycystic kidney disease were the four most frequent original renal diseases leading to altogether 500 kidney transplantations in Rostock from 1976 to 1989. A total of 457 pathomorphological specimen (255 transplant biopsies, 159 explants, 43 postmortem grafts) of 348 renal transplants was histologically studied. The most striking findings were a more frequent hyperacute rejection and an earlier loss of explants as well as a higher incidence of relevant vascular rejection in graft biopsies of glomerulonephritis versus pyelonephritis patients. The obtained results suggest a possible disposition of recipients with glomerulonephritis to a more rapid and intense graft rejection in comparison to transplant patients with pyelonephritis as underlying renal disease.