Nizze H, Brockmöller S
Verh Dtsch Ges Pathol. 1989;73:233-7.
Glomerulonephritis, pyelonephritis, diabetic nephropathy, and polycystic kidney disease were the four most frequent original renal diseases leading to altogether 500 kidney transplantations in Rostock from 1976 to 1989. A total of 457 pathomorphological specimen (255 transplant biopsies, 159 explants, 43 postmortem grafts) of 348 renal transplants was histologically studied. The most striking findings were a more frequent hyperacute rejection and an earlier loss of explants as well as a higher incidence of relevant vascular rejection in graft biopsies of glomerulonephritis versus pyelonephritis patients. The obtained results suggest a possible disposition of recipients with glomerulonephritis to a more rapid and intense graft rejection in comparison to transplant patients with pyelonephritis as underlying renal disease.
肾小球肾炎、肾盂肾炎、糖尿病肾病和多囊肾病是导致1976年至1989年罗斯托克总共500例肾移植的四种最常见的原发性肾脏疾病。对348例肾移植的457份病理形态学标本（255份移植活检、159份切除标本、43份尸检移植物）进行了组织学研究。最显著的发现是，与肾盂肾炎患者相比，肾小球肾炎患者的移植活检中，超急性排斥反应更频繁，切除标本丧失更早，以及相关血管排斥反应的发生率更高。所得结果表明，与以肾盂肾炎为基础肾病的移植患者相比，肾小球肾炎患者可能更容易发生更快、更强烈的移植排斥反应。
