El-Hiti Gamal A, Smith Keith, Hegazy Amany S, Jones D Heulyn, Kariuki Benson M
Cornea Research Chair, Department of Optometry, College of Applied Medical Sciences, King Saud University, PO Box 10219, Riyadh 11433, Saudi Arabia.
School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff CF10 3AT, Wales.
Acta Crystallogr Sect E Struct Rep Online. 2014 Mar 22;70(Pt 4):o467. doi: 10.1107/S1600536814005996. eCollection 2014 Apr 1.
In the title compound, C20H21N3O2·H2O (EQR·H2O), the quinazoline ring system forms dihedral angles of 53.1 (1) and 85.6 (1)° with the phenyl ring and the amide link, respectively. In the crystal, O-H⋯O hydrogen bonds link two EQR and two water mol-ecules into a centrosymmetric R 4 (4)(18) ring motif. N-H⋯O hydrogen bonds further link these hydrogen-bonded fragments into columns extending in [010].