al-Ali A K, Ahmed M A, al-Idrissi H, al-Sibai M H, al-Mutairy A R, al-Awami M
Department of Biochemistry, College of Medicine and Medical Sciences, King Faisal University, Dammam, Saudi Arabia.
Ann Clin Biochem. 1989 Nov;26 ( Pt 6):477-80. doi: 10.1177/000456328902600603.
The levels of glycated haemoglobin, fetal haemoglobin and methaemoglobin in 618 Saudi subjects were determined. A statistically significant decrease in the percentage of glycated haemoglobin was observed in all haemoglobinopathic groups studied in comparison to normal controls. However, there was no significant difference in the percentage of glycated haemoglobin in patients with sickle cell anaemia when compared with those sickle cell subjects who were also glucose-6-phosphate dehydrogenase deficient. This suggests that there is little survival advantage or disadvantage in the combination of glucose-6-phosphate dehydrogenase deficiency and sickle cell anaemia.
测定了618名沙特受试者的糖化血红蛋白、胎儿血红蛋白和高铁血红蛋白水平。与正常对照组相比，在所有研究的血红蛋白病组中均观察到糖化血红蛋白百分比有统计学意义的下降。然而，与同样缺乏葡萄糖-6-磷酸脱氢酶的镰状细胞受试者相比，镰状细胞贫血患者的糖化血红蛋白百分比没有显著差异。这表明葡萄糖-6-磷酸脱氢酶缺乏症和镰状细胞贫血的组合几乎没有生存优势或劣势。
