采用压力舱方案评估无中耳炎病史幼儿的咽鼓管功能。
Eustachian tube function in young children without a history of otitis media evaluated using a pressure chamber protocol.
作者信息
Swarts John Douglas, Casselbrant Margaretha L, Teixeira Miriam S, Mandel Ellen M, Richert Beverly C, Banks Juliane M, El-Wagaa Jenna, Doyle William J
机构信息
Department of Otolaryngology, Division of Pediatric Otolaryngology, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine , Pittsburgh, PA , USA.
出版信息
Acta Otolaryngol. 2014 Jun;134(6):579-87. doi: 10.3109/00016489.2014.882017.
CONCLUSIONS
Protocol limitations were identified and accounted for in the analysis. Percent gradient equilibrated (PGE) was affected by driving gradient direction in a similar manner to other efficiency measures. A finer resolution of possible age-related changes in eustachian tube opening efficiency is expected with the application of more sophisticated statistical models to the complete dataset at study end.
OBJECTIVE
To report the results of an interim analysis for an ongoing study designed to characterize the age-related changes in eustachian tube opening efficiency measured using a pressure chamber protocol in children without a history of middle ear disease.
METHODS
To date, 41 children aged 3 years without a history of otitis media have been enrolled in a longitudinal study of the age-related changes in eustachian tube function and evaluated at yearly intervals between 3 and 7 years of age. Eustachian tube opening efficiency, the percent of the applied pressure gradient equilibrated by swallowing, was measured by repeat tympanometry during a pressure chamber protocol. Data (120 tests) were analyzed using an ANOVA with variance partitioned by age (3 through 6 years), gradient direction (positive/negative), and ear (left/right).
RESULTS
PGE was higher for left ears and positive driving gradients, but was not different among age groups.
结论
在分析中识别并考虑了方案限制因素。平衡百分比梯度（PGE）受驱动梯度方向的影响，其方式与其他效率指标类似。在研究结束时，将更复杂的统计模型应用于完整数据集，有望更精细地解析咽鼓管开放效率可能与年龄相关的变化。
目的
报告一项正在进行的研究的中期分析结果，该研究旨在描述在无中耳疾病史的儿童中，使用压力室方案测量的咽鼓管开放效率与年龄相关的变化。
方法
迄今为止，41名3岁且无中耳炎病史的儿童已纳入一项关于咽鼓管功能与年龄相关变化的纵向研究，并在3至7岁之间每年进行评估。在压力室方案中，通过重复鼓室图测量咽鼓管开放效率，即通过吞咽平衡的施加压力梯度的百分比。使用方差分析对数据（120次测试）进行分析，方差按年龄（3至6岁）、梯度方向（正/负）和耳朵（左/右）进行划分。
结果
左耳和正驱动梯度的PGE较高，但各年龄组之间无差异。
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