Tomita R, Morita K, Munakata K
First Department of Surgery, Nihon University School of Medicine, Tokyo.
Nihon Heikatsukin Gakkai Zasshi. 1989 Aug;25(4):147-54. doi: 10.1540/jsmr1965.25.147.
The purpose of this study is to examine the role of peptidergic nerves (VIP, Substance P, Neurotensin) in Hirschsprung's disease (aganglionosis) and hypoganglionosis in relation to the normoganlionic state of the colon using a mechanographic technique in vitro. The following results were obtained. 1) Normoganglionic muscle strips demonstrated the presence of intact non-adrenergic inhibitory nerve. The activities of such nerves, however, were reduced in hypoganglionic muscle strips, and were absent in aganglionic muscle strips. 2) Peptidergic nerve activities by VIP, substance P, and Neurotensin were present in normoganglionic muscle strips, while they were reduced in hypoganglionic muscle strips, and absent in aganglionic muscle strips. 3) VIP may act as a neurotransmitter-neuromodulator of non-adrenergic inhibitory nerve, while SP and Neurotensin may act as that of non-cholinergic excitatory nerve with some direct effect on the intestinal muscle.
本研究的目的是使用体外机械记录技术，研究肽能神经（血管活性肠肽、P物质、神经降压素）在先天性巨结肠（无神经节症）和神经节减少症中相对于结肠正常神经节状态的作用。获得了以下结果。1）正常神经节的肌条显示存在完整的非肾上腺素能抑制神经。然而，这种神经的活性在神经节减少的肌条中降低，在无神经节的肌条中则不存在。2）血管活性肠肽、P物质和神经降压素的肽能神经活性在正常神经节的肌条中存在，而在神经节减少的肌条中降低，在无神经节的肌条中不存在。3）血管活性肠肽可能作为非肾上腺素能抑制神经的神经递质-神经调节剂，而P物质和神经降压素可能作为非胆碱能兴奋性神经的神经递质-神经调节剂，对肠肌有一些直接作用。
