Takaki M, Jin J G, Nakayama S
Department of Physiology, Okayama University Medical School, Japan.
Acta Med Okayama. 1989 Dec;43(6):353-7. doi: 10.18926/AMO/30860.
Effects of capsaicin on the circular muscle motility of the isolated guinea-pig ileum were investigated. Capsaicin produced a contraction followed by a relaxation of the circular muscle. Both responses were easily desensitized. As the late relaxation response was not sufficiently intense to be analyzed, the inhibitory effect of capsaicin on substance P-induced contractions was explored. Capsaicin abolished the substance P-induced contractions. This inhibitory effect was not affected by tetrodotoxin, and the effect was desensitized. Therefore, all effects of capsaicin on circular muscle motility seem to be due to the release of sensory neuropeptides, similarly to those elicited in the longitudinal muscle.
研究了辣椒素对离体豚鼠回肠环行肌运动的影响。辣椒素可引起环行肌先收缩后舒张。这两种反应都很容易脱敏。由于后期舒张反应强度不足以进行分析，因此研究了辣椒素对P物质诱导收缩的抑制作用。辣椒素消除了P物质诱导的收缩。这种抑制作用不受河豚毒素的影响，且该作用会脱敏。因此，辣椒素对环行肌运动的所有作用似乎都归因于感觉神经肽的释放，这与在纵行肌中引发的作用类似。
