豚鼠回肠对辣椒素的收缩反应是由于P物质释放的证据。
Evidence that the contractile response of the guinea-pig ileum to capsaicin is due to release of substance P.
作者信息
Barthó L, Holzer P, Lembeck F, Szolcsányi J
出版信息
J Physiol. 1982 Nov;332:157-67. doi: 10.1113/jphysiol.1982.sp014407.
Abstract
- The possible roles of substance P and opioids in the contractile response of the isolated guinea-pig ileum to the sensory stimulant drug capsaicin were investigated, and the contractions were found to be inhibited by about 60% in preparations desensitized to substance P. 2. Contractions evoked by stimulation of the mesenteric nerves in the presence of the adrenergic blocking drug guanethidine were inhibited by about 75% after the ileum had been rendered insensitive to substance P. 3. Atropine partially inhibited the effect of capsaicin. The atropine-resistant component of the contractile response to capsaicin was inhibited by more than 85% in preparations desensitized to substance P and almost abolished by the substance P antagonist, (D-Pro2,D-Trp7,9)-substance P. 4. The opioid peptide (D-Met2, Pro5)-enkephalinamide inhibited, whereas the opiate antagonist naloxone enhanced the atropine-resistant contractions in response to capsaicin. 5. The results indicate that the contractile response of the guinea-pig ileum to capsaicin and mesenteric nerve stimulation is mediated by release of substance P, presumably from sensory nerve endings in the gut. Substance P appears to act on the smooth muscle both directly and indirectly via cholinergic neurones. It is proposed that opioids modulate the non-cholinergic response to capsaicin by inhibiting the release of substance P.
摘要
- 研究了P物质和阿片类物质在豚鼠离体回肠对感觉刺激药物辣椒素的收缩反应中可能发挥的作用，结果发现，在对P物质脱敏的标本中，收缩反应被抑制了约60%。2. 在肾上腺素能阻断药物胍乙啶存在的情况下，刺激肠系膜神经诱发的收缩，在回肠对P物质变得不敏感后，被抑制了约75%。3. 阿托品部分抑制了辣椒素的作用。对辣椒素收缩反应中对阿托品不敏感的部分，在对P物质脱敏的标本中被抑制了超过85%，并且几乎被P物质拮抗剂（D-脯氨酸2，D-色氨酸7,9）-P物质完全消除。4. 阿片肽（D-蛋氨酸2，脯氨酸5）-脑啡肽酰胺抑制了对辣椒素的收缩反应，而阿片拮抗剂纳洛酮增强了对辣椒素的阿托品不敏感收缩。5. 结果表明，豚鼠回肠对辣椒素和肠系膜神经刺激的收缩反应是由P物质的释放介导的，推测P物质来自肠道中的感觉神经末梢。P物质似乎通过胆碱能神经元直接和间接地作用于平滑肌。有人提出，阿片类物质通过抑制P物质的释放来调节对辣椒素的非胆碱能反应。
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