Huang Ying, Zhang Qing-Song, Fang Ping, Chen Tie-Gen, Zhu Jun, Hou Xue-Long
State Key Laboratory of Physical Chemistry of Solid Surfaces Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
Chem Commun (Camb). 2014 Jun 28;50(51):6751-3. doi: 10.1039/c4cc02158d.
Highly efficient Pd-catalyzed asymmetric allylic alkylation reaction of ethyl-2-fluoro-2-(diethoxyphosphoryl)acetate with monosubstituted allylic substrates has been developed, affording corresponding α-fluorophosphonates with two chiral centers in high regio-, diastereo- and enantio-selectivities. The usefulness of the products in organic synthesis has been demonstrated.
已开发出高效的钯催化2-氟-2-(二乙氧基磷酰基)乙酸乙酯与单取代烯丙基底物的不对称烯丙基烷基化反应，以高区域选择性、非对映选择性和对映选择性得到具有两个手性中心的相应α-氟膦酸酯。已证明该产物在有机合成中的实用性。
