Cohen Marc D, Keystone Edward C
Mayo Clinic, 668 Humboldt St, Denver, CO 80218, USA.
Expert Rev Clin Immunol. 2014 Jul;10(7):823-30. doi: 10.1586/1744666X.2014.918847. Epub 2014 May 15.
Intravenous golimumab in a dosage of 2 mg/kg, initially given every 4 weeks but then every 8 weeks, in addition to methotrexate, is effective in the treatment of patients with rheumatoid arthritis. This weight-based infusion is administered over thirty minutes with an acceptable safety profile. Since it is a relatively new formulation, more time will be required to assess its specific role in the rheumatologists' armamentarium and to appreciate more fully its long-term safety.
静脉注射戈利木单抗，剂量为2mg/kg，最初每4周给药一次，之后每8周给药一次，联合甲氨蝶呤，对类风湿关节炎患者的治疗有效。这种基于体重的输注在30分钟内给药，安全性良好。由于它是一种相对较新的制剂，需要更多时间来评估其在风湿病学家治疗手段中的具体作用，并更全面地了解其长期安全性。
