Bonelli Michael, Shih Han-Yu, Hirahara Kiyoshi, Singelton Kentner, Laurence Arian, Poholek Amanda, Hand Tim, Mikami Yohei, Vahedi Golnaz, Kanno Yuka, O'Shea John J
Molecular Immunology and Inflammation Branch, National Institutes of Arthritis, and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.
Curr Top Microbiol Immunol. 2014;381:279-326. doi: 10.1007/82_2014_371.
CD4(+) helper T cells are crucial for autoimmune and infectious diseases; however, the recognition of the many, diverse fates available continues unabated. Precisely what controls specification of helper T cells and preserves phenotypic commitment is currently intensively investigated. In this review, we will discuss the major factors that impact helper T cell fate choice, ranging from cytokines and the microbiome to metabolic control and epigenetic regulation. We will also discuss the technological advances along with the attendant challenges presented by "big data," which allow the understanding of these processes on comprehensive scales.
CD4(+)辅助性T细胞对自身免疫性疾病和感染性疾病至关重要;然而,对其多种不同命运的认识仍在持续深入。目前正在深入研究究竟是什么控制着辅助性T细胞的分化并维持其表型稳定性。在这篇综述中,我们将讨论影响辅助性T细胞命运选择的主要因素,从细胞因子、微生物群到代谢控制和表观遗传调控。我们还将讨论技术进步以及“大数据”带来的相关挑战,这些使得我们能够在全面的尺度上理解这些过程。