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[可达龙对不稳定型心绞痛和心肌梗死患者的抗心律失常作用]

[Anti-arrhythmic effect of cordaron in patients with unstable stenocardia and myocardial infarction].

作者信息

Dobrotvorskaia T E, Mustafaev F M, Abdullaeva T I, Matsueva N L

出版信息

Klin Med (Mosk). 1989 Nov;67(11):40-3.

PMID:2483189
Abstract

Antiarrhythmic effect of cordaron in patients with unstable stenocardia (34) and transmural myocardial infarction (39) has been studied in various dose regimens. A dose of 400-600 mg/day was significantly effective in unstable angina pectoris, while in myocardial infarction a 600 mg/day dose failed to attenuate arrhythmia, i.e. the number and frequency of extra-systoles reduced insignificantly. In subacute disease a 200 mg/day cordaron could not prevent an increment of arrhythmia showing inadequacy of a standard scheme of the drug administration.

摘要

已对不同剂量方案下可达龙对不稳定型心绞痛患者(34例)和透壁性心肌梗死患者(39例)的抗心律失常作用进行了研究。400 - 600毫克/天的剂量对不稳定型心绞痛有显著疗效,而在心肌梗死患者中,600毫克/天的剂量未能减轻心律失常,即早搏的数量和频率减少不明显。在亚急性期疾病中,200毫克/天的可达龙无法预防心律失常的增加,这表明该药物的标准给药方案并不充分。

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