Ismail Zahinoor, Malick Arfeen, Smith Eric E, Schweizer Tom, Fischer Corinne
Hotchkiss Brain Institute, University of Calgary, Calgary, Canada.
Neurodegener Dis Manag. 2014;4(2):119-26. doi: 10.2217/nmt.14.5.
Cognitive impairment has long been identified as a component of late-life depression (LLD), and depressive symptoms are common in neurodegeneration. Depression may confer a greater risk of cognitive decline in a cognitively intact population and further cognitive decline in a mild cognitive impairment population compared with those without depression. Exploration of the link between cognitive impairment in LLD and the depressive features of neurodegeneration is an essential part of a diagnostic algorithm. In this review, we will discuss these links; we will address depressive symptoms as a risk factor for dementia and as a prodrome to dementia. We will review clinical subtypes and imaging markers as predictors of development of dementia in depressed patients and explore vascular etiologies. We will also explore LLD and dementia as a spectrum, rather than mutually exclusive diagnostic entities.
长期以来，认知障碍一直被视为老年期抑郁症（LLD）的一个组成部分，而抑郁症状在神经退行性变中很常见。与无抑郁症者相比，抑郁症可能使认知功能正常人群发生认知衰退的风险更高，使轻度认知障碍人群的认知衰退进一步加重。探究LLD中的认知障碍与神经退行性变的抑郁特征之间的联系是诊断算法的重要组成部分。在本综述中，我们将讨论这些联系；我们将探讨抑郁症状作为痴呆症的危险因素以及作为痴呆症前驱症状的情况。我们将回顾临床亚型和影像学标志物作为抑郁症患者发生痴呆症的预测指标，并探讨血管病因。我们还将探讨LLD和痴呆症是一个连续谱，而非相互排斥的诊断实体。
