Ortiz-Espejo María, Pérez-Navero Juan Luis, Olza-Meneses Josune, Muñoz-Villanueva María Carmen, Aguilera-García Concepción María, Gil-Campos Mercedes
Unit of Metabolism and Pediatric Research. IMIBIC, Reina Sofia University Hospital, University of Córdoba,Avenida Menéndez Pidal s/n,CP 14004Córdoba,Spain.
Department of Biochemistry and Molecular Biology II,Institute of Nutrition and Food Technology, Center of Biomedical Research, Lab 123, University of Granada,Armilla,Spain.
Br J Nutr. 2014 Aug 14;112(3):338-46. doi: 10.1017/S0007114514000920. Epub 2014 May 15.
Intra-uterine growth restriction (IUGR) may induce significant metabolic and inflammatory anomalies, increasing the risk of obesity and CVD later in life. Similarly, alterations in the adipose tissue may lead to metabolic changes in children with a history of extra-uterine growth restriction (EUGR). These mechanisms may induce alterations in immune response during early life. The aim of the present study was to compare pro-inflammatory markers in prepubertal EUGR children with those in a reference population. A total of thirty-eight prepubertal children with a history of EUGR and a reference group including 123 healthy age- and sex-matched children were selected. Perinatal data were examined. In the prepubertal stage, the concentrations of inflammatory biomarkers were measured in both groups. The serum concentrations of C-reactive protein (CRP) and plasma concentrations of hepatocyte growth factor (HGF), IL-6, IL-8, monocyte chemotactic protein type 1 (MCP-1), neural growth factor, TNF-α and plasminogen activator inhibitor type 1 were determined. The plasma concentrations of inflammatory biomarkers CRP, HGF, IL-8, MCP-1 and TNF-α were higher in the EUGR group than in the reference group (P< 0·001). After adjustment for gestational age, birth weight and length, blood pressure values and TNF-α concentrations remained higher in the EUGR group than in the reference group. Therefore, further investigations should be conducted in EUGR children to evaluate the potential negative impact of metabolic, nutritional and pro-inflammatory changes induced by the EUGR condition.
宫内生长受限（IUGR）可能会引发显著的代谢和炎症异常，增加日后肥胖和心血管疾病（CVD）的风险。同样，脂肪组织的改变可能会导致有宫外生长受限（EUGR）病史儿童的代谢变化。这些机制可能会在生命早期引发免疫反应的改变。本研究的目的是比较青春期前EUGR儿童与参照人群的促炎标志物。共选取了38名有EUGR病史的青春期前儿童以及一个包含123名年龄和性别匹配的健康儿童的参照组。对围产期数据进行了检查。在青春期前阶段，测量了两组儿童的炎症生物标志物浓度。测定了血清C反应蛋白（CRP）浓度以及血浆中肝细胞生长因子（HGF）、白细胞介素-6（IL-6）、白细胞介素-8（IL-8）、单核细胞趋化蛋白-1（MCP-1）、神经生长因子、肿瘤坏死因子-α（TNF-α）和纤溶酶原激活物抑制剂-1的浓度。EUGR组的血浆炎症生物标志物CRP、HGF、IL-8、MCP-1和TNF-α浓度高于参照组（P<0.001）。在对胎龄、出生体重和身长、血压值进行校正后，EUGR组的血压值和TNF-α浓度仍高于参照组。因此，应对EUGR儿童进行进一步研究，以评估EUGR状况所引发的代谢、营养和促炎变化的潜在负面影响。
