根西岛奶牛BoLA基因多态性的初步报告。

Preliminary report on BoLA polymorphism in Guernsey cattle.

作者信息

Nonnecke B J, Lewin H A, Timms L L

机构信息

National Animal Disease Center, US Department of Agriculture, Ames, IA 50010.

出版信息

J Dairy Sci. 1989 Dec;72(12):3255-8. doi: 10.3168/jds.S0022-0302(89)79485-6.

DOI:10.3168/jds.S0022-0302(89)79485-6

PMID:2483405

Abstract

A total of 95 registered Guernsey cows and heifers sired by 34 bulls were typed for class I antigens encoded by the bovine major histocompatibility complex (BoLA). A panel of alloantisera was used to detect 21 of the 33 internationally recognized BoLA specificities. Fourteen BoLA specificities were detected in the herd using a standard lymphocyte microcytotoxicity test. The most frequent BoLA specificity detected was w6; but in 85% of these animals, a subtype of w6, either w17 (13.7%) or UR6.2 (34.7%), could be assigned. The next most common BoLA specificities, by frequency, were w12, w15, UR1, and w21. Specificities not detected were w2, w3, w5, w7, w11, w16, w19, w20, and w24.

摘要

对由34头公牛所生的95头已注册的根西奶牛和小母牛进行了牛主要组织相容性复合体（BoLA）编码的I类抗原分型。使用一组同种抗血清检测了33种国际公认的BoLA特异性中的21种。采用标准淋巴细胞微量细胞毒性试验在牛群中检测到了14种BoLA特异性。检测到的最常见的BoLA特异性是w6；但在这些动物中，85%的w6存在一个亚型，即w17（13.7%）或UR6.2（34.7%）。按出现频率排序，接下来最常见的BoLA特异性是w12、w15、UR1和w21。未检测到的特异性是w2、w3、w5、w7、w11、w16、w19、w20和w24。