结直肠癌病理生理学中的新细胞内及分子层面研究
New intracellular and molecular aspects in pathophysiology of colorectal cancer.
作者信息
Ziapour Payman, Ataee Ramin, Shadifar Mohammad, Vaillancourt Cathy, Ahmadi Ali, Jafari-Sabet Majid, Ataee Amin
机构信息
Cell and Molecular Research Lab, Amol Research Center, Pasteur Institute of Iran, Amol, Iran ; Parasitiology Department, Amol Research Center, Pasteur Institute of Iran, Amol, Iran.
Cell and Molecular Research Lab, Amol Research Center, Pasteur Institute of Iran, Amol, Iran.
出版信息
Gastroenterol Hepatol Bed Bench. 2011 Spring;4(2):43-52.
Colorectal cancer is one of the most common malignancy in the world and the second cancer-related death, many molecular and genetic aspects of this disease have been cleared as chromosomal instability and the role of some key proteins as WNT/β catenin, trypsin and others. Also recently the role of folate turnover and some neurotransmitters as serotonin were also considered. The scope of this review is to describe some details about new molecular pathways suggested for occurrence or progress of this disease.
结直肠癌是世界上最常见的恶性肿瘤之一，也是癌症相关死亡的第二大原因。这种疾病的许多分子和遗传方面已经明确，如染色体不稳定以及一些关键蛋白（如WNT/β连环蛋白、胰蛋白酶等）的作用。最近，叶酸代谢和一些神经递质（如血清素）的作用也被考虑在内。本综述的范围是描述一些关于该疾病发生或进展所提出的新分子途径的细节。
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