Amado Nathália G, Predes Danilo, Moreno Marcela M, Carvalho Igor O, Mendes Fábio A, Abreu José G
Biomedical Science Institute, Federal University of Rio de Janeiro, Bloco F2 Sala 15, Rio de Janeiro 21949-590, Brazil.
Int J Mol Sci. 2014 Jul 8;15(7):12094-106. doi: 10.3390/ijms150712094.
It is now well documented that natural products have played an important role in anticancer therapy. Many studies focus on the ability of these natural compounds to modulate tumor-related signaling pathways and the relationship of these properties to an anticancer effect. According to the World Health Organization (WHO), colorectal cancer (CRC) is the third most common cancer and the fourth leading cause of cancer death among men and women. Therefore, finding strategies to fight against CRC is an emergent health problem. CRC has a strong association with deregulation of Wnt/β-catenin signaling pathway. As some types of natural compounds are capable of modulating the Wnt/β-catenin signaling, one important question is whether they could counteract CRC. In this review, we discuss the role of flavonoids, a class of natural compounds, on Wnt/β-catenin regulation and its possible potential for therapeutic usage on colorectal cancer.
目前已有充分文献证明，天然产物在抗癌治疗中发挥了重要作用。许多研究聚焦于这些天然化合物调节肿瘤相关信号通路的能力，以及这些特性与抗癌效果之间的关系。根据世界卫生组织（WHO）的数据，结直肠癌（CRC）是第三大常见癌症，也是男性和女性癌症死亡的第四大主要原因。因此，寻找对抗CRC的策略是一个紧迫的健康问题。CRC与Wnt/β-连环蛋白信号通路失调密切相关。由于某些类型的天然化合物能够调节Wnt/β-连环蛋白信号，一个重要的问题是它们是否能够对抗CRC。在本综述中，我们讨论了一类天然化合物——黄酮类化合物在Wnt/β-连环蛋白调节中的作用及其在结直肠癌治疗中的潜在应用可能性。
