Safar M E, Pannier B, Laurent S, London G M
Department of Internal Medicine, Broussais Hospital, Paris, France.
J Cardiovasc Pharmacol. 1989;14 Suppl 10:S1-6; discussion S59-62.
Calcium-entry blockers dilate small arteries as well as large arteries, particularly in the brachial and the carotid circulations. This dilating effect is associated with an increase in systemic and brachial arterial compliance, which is poorly related to the level in blood pressure. Calcium-entry blockers are able to reverse the reduced arterial compliance observed in patients with essential hypertension, with important consequences to the structure and function of the heart and large vessels.
钙通道阻滞剂可扩张小动脉和大动脉，尤其是在肱动脉和颈动脉循环中。这种扩张作用与全身和肱动脉顺应性增加有关，而这与血压水平关系不大。钙通道阻滞剂能够逆转原发性高血压患者中观察到的动脉顺应性降低，这对心脏和大血管的结构和功能具有重要影响。
