Gozariu L, Orbai P, Barabaş E, Strîmbu M G
Department of Endocrinology, Institute of Medicine and Pharmacy, Cluj-Napoca, Romania.
Endocrinologie. 1989 Oct-Dec;27(4):231-5.
The calcium channel activator BAY-K 8644 injected intravenously produces a significant rise in the calcitonin content of the thyroid. Because adrenalin and noradrenaline play a certain role in the regulation of ionic calcium channels and in the preservation of the secretory tonus of the calcitonin secreting C cells, the effect of BAY-K 8644 was followed-up in adrenalectomized animals and in animals in which propranolol was previously administered. Adrenalectomy of beta receptor blocking does not prevent the effect of BAY-K 8644 on the activation of calcium channels, the calcitonin secretion being stimulated in these conditions too. The data obtained stress the relative independence of the calcium channels or the beta-adrenergic stimulating system in the achievement of calcium ion transfer. However, the calcitonin levels obtained were lower in adrenalectomized animals or following propranolol after stimulation with BAY-K 8644 in those with intact sympatho-adrenergic tonus. This stresses the importance of the integrity of the beta receptors in the activation of the calcium channels.
静脉注射钙通道激活剂BAY-K 8644会使甲状腺降钙素含量显著升高。由于肾上腺素和去甲肾上腺素在离子钙通道的调节以及降钙素分泌C细胞分泌张力的维持中发挥一定作用，因此对肾上腺切除动物和预先给予普萘洛尔的动物进行了BAY-K 8644作用的后续研究。肾上腺切除或β受体阻断并不妨碍BAY-K 8644对钙通道激活的作用，在这些情况下降钙素分泌也会受到刺激。所获得的数据强调了钙通道或β-肾上腺素能刺激系统在实现钙离子转运方面的相对独立性。然而，在具有完整交感-肾上腺素能张力的动物中，用BAY-K 8644刺激后，肾上腺切除动物或给予普萘洛尔后的降钙素水平较低。这强调了β受体完整性在钙通道激活中的重要性。
