Matsumoto Rae R, Seminerio Michael J, Turner Ryan C, Robson Matthew J, Nguyen Linda, Miller Diane B, O'Callaghan James P
Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, WV 26506, USA; Center for Neuroscience, School of Medicine, West Virginia University, Morgantown, WV 26506, USA.
Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, WV 26506, USA; Department of Medicine, University of Chicago, Chicago, IL 60637, USA.
Pharmacol Ther. 2014 Oct;144(1):28-40. doi: 10.1016/j.pharmthera.2014.05.001. Epub 2014 May 14.
Reports of methamphetamine-related emergency room visits suggest that elevated body temperature is a universal presenting symptom, with lethal overdoses generally associated with extreme hyperthermia. This review summarizes the available information on methamphetamine toxicity as it pertains to elevations in body temperature. First, a brief overview of thermoregulatory mechanisms is presented. Next, central and peripheral targets that have been considered for potential involvement in methamphetamine hyperthermia are discussed. Finally, future areas of investigation are proposed, as further studies are needed to provide greater insight into the mechanisms that mediate the alterations in body temperature elicited by methamphetamine.
与甲基苯丙胺相关的急诊室就诊报告表明，体温升高是一种普遍出现的症状，致死性过量用药通常与极度高热有关。本综述总结了与甲基苯丙胺毒性相关的、与体温升高有关的现有信息。首先，简要概述体温调节机制。接下来，讨论了被认为可能参与甲基苯丙胺所致高热的中枢和外周靶点。最后，提出了未来的研究领域，因为需要进一步的研究来更深入地了解介导甲基苯丙胺引起的体温变化的机制。
