Division of Molecular and Developmental Biology, National Institute of Genetics, 1111 Yata, Mishima, Shizuoka 411-8540, Japan.
Division of Molecular and Developmental Biology, National Institute of Genetics, 1111 Yata, Mishima, Shizuoka 411-8540, Japan.
Dev Biol. 2014 Aug 1;392(1):1-14. doi: 10.1016/j.ydbio.2014.05.004. Epub 2014 May 14.
The lateral line system of teleost fish is composed of mechanosensory receptors (neuromasts), comprising superficial receptors and others embedded in canals running under the skin. Canal diameter and size of the canal neuromasts are correlated with increasing body size, thus providing a very simple system to investigate mechanisms underlying the coordination between organ growth and body size. Here, we examine the development of the trunk lateral line canal system in zebrafish. We demonstrated that trunk canals originate from scales through a bone remodeling process, which we suggest is essential for the normal growth of canals and canal neuromasts. Moreover, we found that lateral line cells are required for the formation of canals, suggesting the existence of mutual interactions between the sensory system and surrounding connective tissues.
硬骨鱼类的侧线系统由机械感受器（毛细胞）组成，包括位于皮肤下的浅部感受器和其他位于管道中的感受器。管道直径和管道毛细胞的大小与身体尺寸的增加相关，因此提供了一个非常简单的系统来研究器官生长和身体尺寸之间协调的机制。在这里，我们研究了斑马鱼躯干侧线管道系统的发育。我们证明了躯干管道通过骨骼重塑过程从鳞片中起源，我们认为这对于管道和管道毛细胞的正常生长是必不可少的。此外，我们发现侧线细胞对于管道的形成是必需的，这表明感觉系统和周围结缔组织之间存在相互作用。
