Marzok Mohamed A, El-Khodery Sabry A, Oheida Aiman H
Department of Veterinary Surgery, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafr El-Sheikh, 33516, Egypt.
Vet Ophthalmol. 2014 Jul;17 Suppl 1:149-53. doi: 10.1111/vop.12181. Epub 2014 May 19.
To evaluate the effect of intravenous administration of romifidine on the intraocular pressure (IOP) in horses.
Twenty-four horses with no ocular abnormalities.
Horses were randomly assigned into two equal groups (treatment and control). All horses in the treatment group received an intravenous (IV) injection of romifidine (40 μg/kg). The horses in the control group were administrated an intravenous injection of 0.9% saline (0.4 mL/100 kg). In both groups, the IOP values were measured immediately (T0 ) pre-administration and at 5 (T5 ), 15 (T15 ), 30 (T30 ), 45 (T45 ), 60 (T60 ), 90 (T90 ), and 120 (T120 ) min after drug administration.
The pre-treatment values (T0 ) of IOP for right and left eyes were 24.25 ± 3.5 and 25.16 ± 3.4 mmHg, respectively. A significant decrease in IOP values was observed in both right and left eyes of the horses in treatment group at T5 , T15 , T30 , T45 , T60 , and T90 in comparison with the baseline values (P < 0.05). The lowest level of IOP in romifidine-treated groups was recorded at T45 for the right and left eyes (10.25 ± 2.3 and 11.25 ± 3.5 mmHg, respectively).
Romifidine significantly decreased IOP in clinically normal horses and may be used safely for surgery or diagnostic ocular procedures in horses when specific control of IOP is required.
评估静脉注射罗米非定对马眼压（IOP）的影响。
24匹无眼部异常的马。
将马随机分为两组（治疗组和对照组），每组数量相等。治疗组所有马匹静脉注射罗米非定（40μg/kg），对照组马匹静脉注射0.9%生理盐水（0.4mL/100kg）。两组均在给药前即刻（T0）以及给药后5（T5）、15（T15）、30（T30）、45（T45）、60（T60）、90（T90）和120（T120）分钟测量眼压值。
右眼和左眼眼压的治疗前值（T0）分别为24.25±3.5和25.16±3.4mmHg。与基线值相比，治疗组马匹的右眼和左眼在T5、T15、T30、T45、T60和T90时眼压值均显著降低（P<0.05）。罗米非定治疗组眼压的最低水平在T45时记录，右眼和左眼分别为10.25±2.3和11.25±3.5mmHg。
罗米非定可显著降低临床正常马匹的眼压，在需要特定眼压控制时，可安全用于马匹的手术或眼部诊断程序。
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