声学辐射力脉冲弹性成像用于原发性胆汁性肝硬化患者疾病分期的无创评估：一项初步研究。
Acoustic radiation force impulse elastography for non-invasive assessment of disease stage in patients with primary biliary cirrhosis: A preliminary study.
作者信息
Zhang D-K, Chen M, Liu Y, Wang R-F, Liu L-P, Li M
机构信息
Department of Ultrasound, The 302 Hospital of PLA, 100039 Beijing, China.
Department of Ultrasound, The 302 Hospital of PLA, 100039 Beijing, China.
出版信息
Clin Radiol. 2014 Aug;69(8):836-40. doi: 10.1016/j.crad.2014.03.019. Epub 2014 May 16.
AIM
To investigate the diagnostic performance of the acoustic radiation force impulse (ARFI) elastography for the assessment of primary biliary cirrhosis (PBC) stage.
MATERIALS AND METHODS
Sixty-one patients with PBC in which liver biopsy and ARFI elastography measurements were performed in the same session were included in the study. The diagnostic performance of ARFI elastography for predicting the PBC stage was determined from the area under receiver operating characteristics (AUROC) curve analysis.
RESULTS
ARFI elastography correlated significantly with histological stage (r = 0.74, p < 0.001) in patients with PBC. The AUROC of ARFI elastography for predicting histological stage equal to or higher than II, III, and equal to IV were 0.83, 0.93, and 0.91, respectively. The optimal cut-off values of ARFI elastography were 1.51 m/s, 1.79 m/s, and 2.01 m/s for PBC stage equal to or higher than II, III, and equal to IV, respectively.
CONCLUSION
ARFI elastography is an acceptable and powerful technique for quantitative assessment of PBC stage.
目的
研究声辐射力脉冲（ARFI）弹性成像技术在评估原发性胆汁性肝硬化（PBC）分期中的诊断性能。
材料与方法
本研究纳入61例同期进行肝脏活检及ARFI弹性成像测量的PBC患者。通过受试者操作特征（AUROC）曲线分析确定ARFI弹性成像预测PBC分期的诊断性能。
结果
PBC患者中，ARFI弹性成像与组织学分期显著相关（r = 0.74，p < 0.001）。ARFI弹性成像预测组织学分期为II期及以上、III期及以上、IV期的AUROC分别为0.83、0.93和0.91。ARFI弹性成像预测PBC分期为II期及以上、III期及以上、IV期的最佳截断值分别为1.51 m/s、1.79 m/s和2.01 m/s。
结论
ARFI弹性成像是一种可接受且有效的定量评估PBC分期的技术。
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