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急性心肌梗死合并室间隔破裂的紧急杂交治疗方法

Urgent hybrid approach in treatment of the acute myocardial infarction complicated by the ventricular septal rupture.

作者信息

Radosavljević-Radovanović Mina, Radovanović Nebojsa, Arandjelović Aleksandra, Mitrović Predrag, Usćumlić Ana, Stanković Goran

出版信息

Srp Arh Celok Lek. 2014 Mar-Apr;142(3-4):226-8. doi: 10.2298/sarh1404226r.

DOI:10.2298/sarh1404226r
PMID:24839780
Abstract

INTRODUCTION

Ventricular septal rupture (VSR) in the acute myocardial infarction (AMI) is a rare but very serious complication, still associated with high mortality, despite significant improvements in pharmacological and surgical treatment. Therefore, hybrid approaches are introduced as new therapeutical options.

CASE OUTLINE

We present an urgent hybrid approach, consisting of the initial percutaneous coronary intervention (PCI) of the infarct-related artery, followed by immediate surgical closure of the ventricular septal rupture, for treatment of high risk, hemodynamically unstable female patient with AMI caused by one-vessel disease and complicated by VSR and cardiogenic shock. Since the operative risk was also very high (EUROSCORE II 37%), this therapeutic decision was based on the assumption that preoperative PCI could promptly establish blood flow and thereby lessen the risks, duration and complexity of urgent cardiosurgical intervention, performed on the same day. This approach proved to be successful and the patient was discharged from the hospital on the fifteenth postoperative day in stable condition.

CONCLUSION

In selected cases, with high operative risk and unstable hemodynamic state due to AMI complicated by VSR, urgent hybrid approach consisting of the initial PCI followed by surgical closure of VSR may represent an acceptable treatment option and contribute to the treatment of this complex group of patients.

摘要

引言

急性心肌梗死(AMI)合并室间隔破裂(VSR)是一种罕见但非常严重的并发症,尽管药物和手术治疗有了显著改善,但死亡率仍然很高。因此,混合治疗方法作为新的治疗选择被引入。

病例概述

我们介绍一种紧急混合治疗方法,包括对梗死相关动脉进行初始经皮冠状动脉介入治疗(PCI),随后立即手术闭合室间隔破裂,用于治疗因单支血管病变导致AMI并合并VSR和心源性休克的高危、血流动力学不稳定的女性患者。由于手术风险也非常高(欧洲心脏手术风险评估系统II为37%),这一治疗决策基于术前PCI能够迅速建立血流,从而降低在同一天进行的紧急心脏手术干预的风险、持续时间和复杂性这一假设。该方法被证明是成功的,患者在术后第15天病情稳定出院。

结论

在因AMI合并VSR导致手术风险高且血流动力学状态不稳定的特定病例中,由初始PCI followed by surgical closure of VSR组成的紧急混合治疗方法可能是一种可接受的治疗选择,并有助于治疗这一复杂的患者群体。 (注:原文中“followed by surgical closure of VSR”这里表述有误,应改为“followed by immediate surgical closure of the ventricular septal rupture”,已按正确意思翻译)

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