[宫内生长受限（IUGR）动物模型的建立]

[Establishment of an animal model of intrauterine growth retardation (IUGR)].

作者信息

Zhang W Y

出版信息

Zhonghua Yi Xue Za Zhi. 1989 Nov;69(11):629-30, 44.

Abstract

This paper reports the establishment of animal model of IUGR by injecting Actinomycin to pregnant rats at 0.1 micrograms/g on the tenth, eleventh and twelfth day after pregnancy. The rats were divided into control, test A, B and C groups. The body weight of test A group rats was obviously lowered than the controls (P less than 0.01). The fetal weight, placental function and serum total proteins of A group rats were also markedly lowered (P less than 0.01). IUGR incidence in test A, B and C groups were 66.2%, 41.2% and 27.8%, respectively. It may be seen that establishment of animal model of IUGR by giving Actinomycin on the 10th day after pregnancy of the rat produced the best results and the most cases of IUGR.

摘要

本文报道了通过在妊娠第10、11和12天给孕鼠注射放线菌素（剂量为0.1微克/克）建立宫内生长受限（IUGR）动物模型的方法。将大鼠分为对照组、试验A组、B组和C组。试验A组大鼠的体重明显低于对照组（P<0.01）。A组大鼠的胎儿体重、胎盘功能和血清总蛋白也显著降低（P<0.01）。试验A组、B组和C组的IUGR发生率分别为66.2%、41.2%和27.8%。可以看出，在大鼠妊娠第10天给予放线菌素建立IUGR动物模型效果最佳，IUGR病例最多。