中链脂肪酸盐对亲水性化合物和大分子化合物透过兔角膜的影响。

Effect of medium-chain fatty acid salts on penetration of a hydrophilic compound and a macromolecular compound across rabbit corneas.

作者信息

Morimoto K, Nakamura T, Morisaka K

机构信息

Department of Pharmaceutics, Osaka University of Pharmaceutical Sciences, Japan.

出版信息

Arch Int Pharmacodyn Ther. 1989 Nov-Dec;302:18-26.

PMID:2484010

Abstract

The effects of sodium salts of medium-chain fatty acids, caprylate and caprate, on the penetration of a hydrophilic compound and a macromolecular compound across rabbit corneas in vitro were examined. Sodium caprylate (0.5 and 1% 2/v) marginally increased the corneal penetration of 6-carboxyfluorescein, a hydrophilic compound. However, it did not change the corneal penetration of FITC-dextran (mol.wt 4000). Sodium caprate (0.5 and 1% w/v) markedly increased the corneal penetration of these compounds.

摘要

研究了中链脂肪酸的钠盐（辛酸盐和癸酸盐）对亲水性化合物和大分子化合物体外透过兔角膜的影响。辛酸钠（0.5%和1%，w/v）略微增加了亲水性化合物6-羧基荧光素的角膜透过率。然而，它并未改变异硫氰酸荧光素-葡聚糖（分子量4000）的角膜透过率。癸酸钠（0.5%和1%，w/v）显著增加了这些化合物的角膜透过率。