Effect of medium-chain fatty acid salts on penetration of a hydrophilic compound and a macromolecular compound across rabbit corneas.
作者信息
Morimoto K, Nakamura T, Morisaka K
机构信息
Department of Pharmaceutics, Osaka University of Pharmaceutical Sciences, Japan.
出版信息
Arch Int Pharmacodyn Ther. 1989 Nov-Dec;302:18-26.
PMID:2484010
Abstract
The effects of sodium salts of medium-chain fatty acids, caprylate and caprate, on the penetration of a hydrophilic compound and a macromolecular compound across rabbit corneas in vitro were examined. Sodium caprylate (0.5 and 1% 2/v) marginally increased the corneal penetration of 6-carboxyfluorescein, a hydrophilic compound. However, it did not change the corneal penetration of FITC-dextran (mol.wt 4000). Sodium caprate (0.5 and 1% w/v) markedly increased the corneal penetration of these compounds.
摘要
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