Durán W N, Dillon P K
Department of Physiology, UMDNJ-New Jersey Medical School 07103-2757.
Microcirc Endothelium Lymphatics. 1989 Jun-Oct;5(3-5):223-39.
Microvascular permeability changes (using FITC-dextran 150 clearance as an index) produced by ischemia-reperfusion (I-R) were investigated in the rat cremaster muscle. I-R produced significant sustained increases in microvascular permeability to macromolecules. Pretreatment with dexamethasone and verapamil reduced this I-R effect. Leukopenia also afforded protection to the microcirculation. It was concluded that changes occurring during ischemia are major causative components of the ischemia-reperfusion damage.
在大鼠提睾肌中研究了缺血再灌注（I-R）引起的微血管通透性变化（以异硫氰酸荧光素标记的葡聚糖150清除率为指标）。I-R导致微血管对大分子的通透性显著持续增加。地塞米松和维拉帕米预处理可减轻这种I-R效应。白细胞减少也对微循环起到保护作用。得出的结论是，缺血期间发生的变化是缺血再灌注损伤的主要致病因素。
