Miyata M, Yamashita H, Shirakata S, Takeda Z
Neurol Med Chir (Tokyo). 1989 Dec;29(12):1148-52. doi: 10.2176/nmc.29.1148.
A 24-year-old female was hospitalized for progressive headache and nausea. Computed tomography showed a mass lesion in the left lateral ventricle near the foramen of Monro. On light microscopy, this tumor morphologically resembled an oligodendroglioma. However, ultrastructural examination disclosed synapses and neuronal differentiation. Review of the literature revealed 21 cases of intraventricular neuronal tumors in adults that were diagnosed as central neurocytoma or differentiated neuroblastoma. Fourteen of the 21 patients were males and seven were females. Their ages ranged from 16 to 52 years and averaged 30.7 years. All of the tumors were located near the foramen of Monro and the clinical symptoms were primarily headache and nausea. The outcome was generally good. Surgical removal was the most effective treatment, whereas the effect of radiation therapy was unclear. The diagnosis requires demonstration of neuronal differentiation. Generally, the diagnosis is neurocytoma if the neuronal tissue is mature, with complete synapses, and neuroblastoma if it is immature. However, the criteria for differentiation between these two tumors are still controversial.
一名24岁女性因进行性头痛和恶心入院。计算机断层扫描显示在左侧脑室靠近孟氏孔处有一个占位性病变。光镜下，该肿瘤在形态上类似于少突胶质细胞瘤。然而，超微结构检查发现了突触和神经元分化。文献回顾显示，有21例成人脑室内神经元肿瘤被诊断为中枢神经细胞瘤或分化型神经母细胞瘤。21例患者中14例为男性，7例为女性。他们的年龄在16至52岁之间，平均年龄为30.7岁。所有肿瘤均位于孟氏孔附近，临床症状主要为头痛和恶心。总体预后良好。手术切除是最有效的治疗方法，而放射治疗的效果尚不清楚。诊断需要证实神经元分化。一般来说，如果神经元组织成熟且有完整突触，则诊断为神经细胞瘤；如果神经元组织不成熟，则诊断为神经母细胞瘤。然而，这两种肿瘤之间的分化标准仍存在争议。
