Department of Medicine Jichi Medical University Saitama Medical Center Saitama Japan.
Department of Biochemistry Jichi Medical University Shimotsuke Tochigi Japan.
J Diabetes Investig. 2012 Dec 20;3(6):526-33. doi: 10.1111/j.2040-1124.2012.00230.x. Epub 2012 Jul 24.
AIMS/INTRODUCTION: The present study was undertaken to determine vascular endothelial impairment and endothelial progenitor cells (EPCs) in patients with type 2 diabetes mellitus and erectile dysfunction (ED).
A total of 100 type 2 diabetic men were enrolled. Flow-mediated dilatation (FMD) and anaerobic threshold (AT) were measured. Also, EPCs in the peripheral blood were determined by flow cytometry.
In the 42 ED diabetic patients, FMD and AT were significantly less than those in the 58 patients with normal erectile function (FMD 2.84 vs 3.82%, P = 0.038, and AT 11.2 vs 12.7 mL/kg/min, P = 0.022). Exercise tolerance significantly increased the number of EPCs in the patients with and without ED (49-60 cells/100 μL, P = 0.015, and 72-99 cells/100 μL, P = 0.003). In the diabetic patients without autonomic neuropathy, FMD was significantly reduced in the patients with ED than those without ED (P = 0.015). In response to exercise tolerance, the number of EPCs increased in both the diabetic patients with ED (P = 0.003) and without ED (P = 0.007). In contrast, in the diabetic patients with autonomic neuropathy, there was no difference in FMD between the patients with and without ED. The exercise tolerance increased the number of EPCs in the patients without ED (P = 0.023), but it disappeared in those with ED.
ED diabetic patients have endothelial impairment during the early period of diabetic complications, whose deranged endothelial function is concomitantly repaired by promoting bone marrow-derived EPCs.
目的/引言：本研究旨在探讨 2 型糖尿病伴勃起功能障碍（ED）患者的血管内皮功能障碍和内皮祖细胞（EPCs）。
共纳入 100 例 2 型糖尿病男性患者。通过血流介导的扩张（FMD）和无氧阈值（AT）来测量。同时，通过流式细胞术检测外周血中的 EPCs。
在 42 例 ED 糖尿病患者中，FMD 和 AT 明显低于 58 例勃起功能正常的患者（FMD：2.84%对 3.82%，P=0.038；AT：11.2 对 12.7 mL/kg/min，P=0.022）。运动耐量显著增加了 ED 和非 ED 患者的 EPC 数量（49-60 个/100 μL，P=0.015；72-99 个/100 μL，P=0.003）。在无自主神经病变的糖尿病患者中，ED 患者的 FMD 明显低于非 ED 患者（P=0.015）。对运动耐量的反应，ED 患者的 EPC 数量增加（P=0.003），而非 ED 患者的 EPC 数量也增加（P=0.007）。相比之下，在有自主神经病变的糖尿病患者中，ED 患者与非 ED 患者之间的 FMD 没有差异。运动耐量增加了非 ED 患者的 EPC 数量（P=0.023），但在 ED 患者中则消失了。
在糖尿病并发症的早期，ED 糖尿病患者即存在血管内皮功能障碍，其受损的内皮功能通过促进骨髓源性 EPC 来修复。
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