Tanaka I, Ishimatsu S, Haratake J, Horie A, Kodama Y
Department of Environmental Health Engineering, University of Occupational and Environmental Health, Kitakyushu, Japan.
Biol Trace Elem Res. 1988 Sep-Dec;17:237-46. doi: 10.1007/BF02795460.
This study reports the biological half-time of amorphous nickel monosulfide(NiS(A)) aerosol retained in rat lungs. Wistar male rats were exposed to NiS(A) aerosols (mass median aerodynamic diameter:4.0 microns) for a single 4 h exposure, or for 7 h/d, 5 d/wk for 1 mo. The average exposure concentrations were controlled at 107 mg/m3 for the single exposure and at 8.8 mg/m3 for the repeated exposures by a dust generator consisting of a continuous fluidized bed with an overflow pipe and a screw feeder. After the exposures, the nickel contents in the rat organs, blood, and urine were measured and histopathological examinations were performed. The biological half time of NiS(A) in rat lungs was 20 h, which was extremely shorter than 21 mo of green nickel oxide (NiO(G)). There were no malignant tumors in any of the exposure groups.
本研究报告了大鼠肺中留存的非晶态硫化镍（NiS(A)）气溶胶的生物半衰期。将雄性Wistar大鼠暴露于NiS(A)气溶胶（质量中位空气动力学直径：4.0微米）中，单次暴露4小时，或每周5天、每天7小时，持续1个月。通过由带溢流管的连续流化床和螺旋进料器组成的粉尘发生器，将单次暴露的平均暴露浓度控制在107毫克/立方米，重复暴露的平均暴露浓度控制在8.8毫克/立方米。暴露后，测量大鼠器官、血液和尿液中的镍含量，并进行组织病理学检查。大鼠肺中NiS(A)的生物半衰期为20小时，这比绿色氧化镍（NiO(G)）的21个月短得多。任何暴露组均未出现恶性肿瘤。
