Ta'naka I, Igisu H, Haratake J, Cho S, Mori K, Fujishiro K, Inoue N, Horie A, Akiyama T
Am Ind Hyg Assoc J. 1987 Apr;48(4):330-4. doi: 10.1080/15298668791384841.
There are few investigations concerning the cumulative toxicity of agricultural chemicals by repeated inhalation. In this study, Wistar male rats were exposed to methomyl powder (mass median aerodynamic diameter, 4.4 microns) for a single 4-hr exposure, or for 4 hr/day, 5 days/week for 3 months. The average exposure concentrations were controlled at 9.9 mg/m3 for the single exposure and at 14.8 mg/m3 for repeated exposures by a dust generator consisting of a continuous fluidized bed with an overflow pipe and a screw feeder. After the repeated exposures, plasma and red cell cholinesterase activities, and lipid concentrations of the rat lungs were measured and histopathological examinations were performed. There was no evidence of cumulative effects on the red cell cholinesterase activity, histopathological changes and lipid concentration in 3-month repeated inhalation.
关于通过反复吸入农用化学品的累积毒性的研究很少。在本研究中，将Wistar雄性大鼠暴露于灭多威粉剂（质量中值空气动力学直径为4.4微米），单次暴露4小时，或每天暴露4小时，每周暴露5天，持续3个月。通过由带溢流管的连续流化床和螺旋进料器组成的粉尘发生器，将单次暴露的平均暴露浓度控制在9.9毫克/立方米，反复暴露的平均暴露浓度控制在14.8毫克/立方米。反复暴露后，测量大鼠血浆和红细胞胆碱酯酶活性以及肺组织脂质浓度，并进行组织病理学检查。在3个月的反复吸入过程中，没有证据表明对红细胞胆碱酯酶活性、组织病理学变化和脂质浓度有累积影响。
