Department of Endocrinology and Metabolism Kyoto Prefectural University of Medicine Graduate School of Medical Science Japan.
Immunology Frontier Research Center at Osaka University Japan.
J Diabetes Investig. 2013 Jul 8;4(4):399-404. doi: 10.1111/jdi.12052. Epub 2013 Mar 4.
AIMS/INTRODUCTION: Recent studies have shown the association between blood pressure variability and cardiovascular events. The present study was designed to investigate the relationship between antihypertensive drug class and home blood pressure variability in patients with type 2 diabetes.
We compared home blood pressure variability among patients treated with calcium channel blockers (n = 44), with angiotensin II receptor blockers and/or angiotensin-converting enzyme inhibitors (n = 159), and with calcium channel blockers combined with angiotensin II receptor blockers and/or angiotensin-converting enzyme inhibitors (n = 183). Next, we analyzed the effect of calcium channel blockers on morning blood pressure variability using multiple linear regression analysis.
Coefficient variation of morning systolic blood pressure in patients treated with calcium channel blockers was significantly lower than that in patients treated with angiotensin II receptor blockers and/or angiotensin-converting enzyme inhibitors (P = 0.036). Multivariate linear regression analyses showed that treatment with calcium channel blockers was significantly correlated with coefficient variation of morning systolic blood pressure (β = -0.264, P = 0.001).
The present study implies a possibility for validity on selecting calcium channel blockers in hypertensive patients with type 2 diabetes to reduce home blood pressure variability.
目的/引言:最近的研究表明血压变异性与心血管事件之间存在关联。本研究旨在探讨 2 型糖尿病患者的降压药物类别与家庭血压变异性之间的关系。
我们比较了接受钙通道阻滞剂(n=44)、血管紧张素 II 受体阻滞剂和/或血管紧张素转换酶抑制剂(n=159)以及钙通道阻滞剂联合血管紧张素 II 受体阻滞剂和/或血管紧张素转换酶抑制剂(n=183)治疗的患者的家庭血压变异性。接下来,我们使用多元线性回归分析分析钙通道阻滞剂对清晨血压变异性的影响。
接受钙通道阻滞剂治疗的患者清晨收缩压变异系数明显低于接受血管紧张素 II 受体阻滞剂和/或血管紧张素转换酶抑制剂治疗的患者(P=0.036)。多元线性回归分析表明,钙通道阻滞剂治疗与清晨收缩压变异系数显著相关(β=-0.264,P=0.001)。
本研究暗示在选择 2 型糖尿病高血压患者的钙通道阻滞剂以降低家庭血压变异性方面具有一定的有效性。