Department of Veterinary Medicine National Chung-Hsing University Taichung Taiwan.
Department of Nursing St. Mary's Medicine Nursing and Management College Yilan Taiwan.
J Diabetes Investig. 2013 Nov 27;4(6):528-32. doi: 10.1111/jdi.12097. Epub 2013 May 8.
AIMS/INTRODUCTION: Previous studies have suggested that chromium (Cr) is an essential cofactor for normal carbohydrate metabolism and affects insulin sensitivity, especially in rodent models. Several factors, such as insulin challenge, high carbohydrate intake, and response to stress (e.g., in obesity), alter Cr excretion or distribution. Glucagon is known to regulate carbohydrate metabolism and hyperglucagonemia plays a role in the development of hyperglycemia in diabetic subjects.
In the present study we investigated possible modulation of Cr levels by glucagon using an obese mouse model. Mice were kept on a high-fat diet and then used as an obesity model. These obese mice were injected with one dose of glucagon or insulin and Cr levels in their tissues were determined.
In obese mice, glucagon challenge significantly increased Cr levels in bone but decreased them in the fat and liver. In contrast, insulin challenge significantly decreased Cr levels in bone but increased them in the fat, liver and muscle.
The results show that glucagon and insulin have opposite effects on Cr levels in bone, fat, liver, and muscle.
目的/引言：先前的研究表明，铬（Cr）是正常碳水化合物代谢的必需辅助因子，并且影响胰岛素敏感性，尤其是在啮齿动物模型中。一些因素，如胰岛素挑战、高碳水化合物摄入以及对压力的反应（例如肥胖），会改变 Cr 的排泄或分布。已知胰高血糖素可调节碳水化合物代谢，而高胰高血糖素血症在糖尿病患者的高血糖发展中起作用。
在本研究中，我们使用肥胖小鼠模型研究了胰高血糖素对 Cr 水平的可能调节作用。将小鼠饲养在高脂肪饮食上，然后用作肥胖模型。这些肥胖小鼠接受了一次胰高血糖素或胰岛素注射，并测定了其组织中的 Cr 水平。
在肥胖小鼠中，胰高血糖素刺激显著增加了骨骼中的 Cr 水平，但降低了脂肪和肝脏中的 Cr 水平。相比之下，胰岛素刺激显著降低了骨骼中的 Cr 水平，但增加了脂肪、肝脏和肌肉中的 Cr 水平。
结果表明，胰高血糖素和胰岛素对骨骼、脂肪、肝脏和肌肉中的 Cr 水平具有相反的作用。
