Olsson H, Bergstrand H
Research and Development Department, AB Draco, Lund, Sweden.
Cell Signal. 1989;1(4):405-10. doi: 10.1016/0898-6568(89)90059-4.
Compound 1,2-isopropylidene-3-decanoyl-sn-glycerol (IpOCOC9) augments the phosphorylation in vitro of histone III-S and myelin basic protein (MBP) by a partially purified Ca2(+)- and phospholipid-dependent protein kinase activity (protein kinase C) from human polymorphonuclear leukocytes. IpOCOC9 can substitute for either Ca2+ and phosphatidylserine or for phorbol ester. The related compound decanoid acid cyclopentyl methylester (DACPME) is less effective than IpOCOC9 in this respect. These data lend support to the notion that the secretagogue activity of IpOCOC9 with respect to human basophil histamine release and neutrophil superoxide radical generation is due to protein kinase C activation.
化合物1,2 - 异亚丙基 - 3 - 癸酰基 - sn - 甘油（IpOCOC9）可增强人多形核白细胞中部分纯化的钙和磷脂依赖性蛋白激酶活性（蛋白激酶C）对组蛋白III - S和髓鞘碱性蛋白（MBP）的体外磷酸化作用。IpOCOC9可以替代钙和磷脂酰丝氨酸或佛波酯。在这方面，相关化合物癸酸环戊基甲酯（DACPME）的效果不如IpOCOC9。这些数据支持了这样一种观点，即IpOCOC9对人嗜碱性粒细胞组胺释放和中性粒细胞超氧自由基生成的促分泌活性是由于蛋白激酶C的激活。
