ω-3脂肪酸受体GPR120在人足月胎盘中的表达与定位
Expression and localization of the omega-3 fatty acid receptor GPR120 in human term placenta.
作者信息
Lager S, Ramirez V I, Gaccioli F, Jansson T, Powell T L
机构信息
Center for Pregnancy and Newborn Research, Department of Obstetrics and Gynecology, University of Texas Health Science Center, San Antonio, TX, USA.
Center for Pregnancy and Newborn Research, Department of Obstetrics and Gynecology, University of Texas Health Science Center, San Antonio, TX, USA.
出版信息
Placenta. 2014 Jul;35(7):523-5. doi: 10.1016/j.placenta.2014.04.017. Epub 2014 May 9.
Abstract
Fatty acids can function as signaling molecules, acting through receptors in the cytosol or on the cell surface. G-Protein Receptor (GPR)120 is a membrane-bound receptor mediating anti-inflammatory and insulin-sensitizing effects of the omega-3 fatty acid docohexaenoic acid (DHA). GPR120 dysfunction is associated with obesity in humans. Cellular localization of GPR120 and the influence of maternal obesity on GPR120 protein expression in the placenta are unknown. Herein we demonstrate that GPR120 is predominantly expressed in the microvillous membrane (MVM) of human placenta and that the expression level of this receptor in MVM is not altered by maternal body mass index (BMI).
摘要
脂肪酸可作为信号分子，通过胞质溶胶或细胞表面的受体发挥作用。G蛋白受体（GPR）120是一种膜结合受体，介导ω-3脂肪酸二十二碳六烯酸（DHA）的抗炎和胰岛素增敏作用。GPR120功能障碍与人类肥胖有关。GPR120的细胞定位以及母体肥胖对胎盘GPR120蛋白表达的影响尚不清楚。在此我们证明，GPR120主要在人胎盘的微绒毛膜（MVM）中表达，并且该受体在MVM中的表达水平不受母体体重指数（BMI）的影响。
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