Mirabeau-Beale Kristina L, Viswanathan Akila N
Harvard Radiation Oncology Program, Boston, MA, USA.
Department of Radiation Oncology, Brigham and Women's Hospital/Dana-Farber Cancer Institute, Boston, MA, USA.
Gynecol Oncol. 2014 Aug;134(2):403-9. doi: 10.1016/j.ygyno.2014.05.008. Epub 2014 May 15.
To summarize the literature on quality of life for patients treated with definitive radiation for gynecologic cancers, with a specific focus on patient reported outcomes.
A literature review was performed to summarize studies about patient-reported outcomes and quality of life in women with gynecologic malignancies who were treated with definitive radiation therapy. Summaries are by disease site, including endometrial, cervical and vulvar cancers.
Over 20 different survey instruments have been used to describe patient-reported outcomes for women treated with radiation for gynecologic cancer. Regardless of disease site, all patients describe a degree of compromise in physical and social functioning, as well as sexual dysfunction. Specific symptoms which are most bothersome for patients vary by disease site, such as bowel concerns predominating for endometrial cancer patients, while body image is more concerning for cervical cancer patients.
Several quality of life concerns exist for women treated with radiation therapy for gynecologic malignancies. Significant overlap exists in the QOL issues affecting these patients. Whether to combine or separate surveys by diagnosis, treatment type, age, or time point should be explored further. Assessing patients' psychological, emotional, and physical concerns helps to understand long-term adjustment, enabling incorporation of these domains into future trials that will ultimately improve patient well-being.
总结关于接受妇科癌症根治性放疗患者生活质量的文献，特别关注患者报告的结局。
进行文献综述，以总结关于接受根治性放射治疗的妇科恶性肿瘤女性患者报告的结局和生活质量的研究。按疾病部位进行总结，包括子宫内膜癌、宫颈癌和外阴癌。
超过20种不同的调查工具已被用于描述接受妇科癌症放疗女性患者报告的结局。无论疾病部位如何，所有患者均描述在身体和社会功能以及性功能方面存在一定程度的损害。对患者来说最困扰的具体症状因疾病部位而异，例如肠道问题在子宫内膜癌患者中占主导，而身体形象对宫颈癌患者来说更受关注。
接受妇科恶性肿瘤放疗的女性存在若干生活质量问题。影响这些患者的生活质量问题存在显著重叠。应进一步探讨是按诊断、治疗类型、年龄或时间点合并还是分开进行调查。评估患者的心理、情感和身体问题有助于了解长期调整情况，从而能够将这些领域纳入最终将改善患者福祉的未来试验中。
