Galli M G, Pugliese M, Guerra M, Zei T
Ann Ig. 1989 Nov-Dec;1(6):1299-306.
Infection with HBV is still one of the more important professional risk for medical staff. This is particularly true for dentists the more so when they are operating in areas at medium or high prevalence of HBsAg carriers. In such situation patients often ignore their carrier state, when they know it they are not always conscious of the importance of notifying the information to their dentist. The dentists, on the other hand, don't routinely collect a detailed anamnesis of their patients. For these reasons the opportunity of being vaccinated against hepatitis B with a DNA recombinant vaccine was offered to dentistry students of the University of Perugia. All participants were to be negative for hepatitis B markers of infection including HBsAg and anti HBs. All volunteers were to have normal aminotransferase levels, be in good physical condition and give their informed written consent. 48 students turned out to be eligible for vaccination, of them 35 were males, 13 females, mean age 23 years. About two months after the third dose, all the vaccinees had seroconverted and 70.4% of them showed antibody titres between 1,000 greater than or equal to 10,000 UI/l. That indicate that very likely the antibody persistence will be long lasting (at least 5 years). Side effects, light and of short duration, were rarely seen.
感染乙肝病毒仍然是医护人员面临的较为重要的职业风险之一。对于牙医来说尤其如此，当他们在乙肝表面抗原携带者中高流行地区开展工作时更是如此。在这种情况下，患者往往忽视自己的携带者状态，即便知道自己是携带者，也并非总是意识到将这一信息告知牙医的重要性。另一方面，牙医通常不会常规收集患者的详细病史。出于这些原因，佩鲁贾大学向牙科专业学生提供了接种重组DNA乙肝疫苗的机会。所有参与者的乙肝感染标志物均应为阴性，包括乙肝表面抗原和乙肝表面抗体。所有志愿者的转氨酶水平应正常，身体状况良好，并给予知情书面同意。结果有48名学生符合接种条件，其中35名男性，13名女性，平均年龄23岁。在接种第三剂疫苗约两个月后，所有接种者均已产生血清转化，其中70.4%的人抗体滴度在1000至10000国际单位/升之间。这表明抗体很可能会长期持续存在（至少5年）。很少出现轻微且持续时间短的副作用。
