Aronsen Dane, Webster Jeremy, Schenk Susan
School of Psychology, Victoria University of Wellington, P.O. Box 600, Wellington, New Zealand.
School of Psychology, Victoria University of Wellington, P.O. Box 600, Wellington, New Zealand.
Pharmacol Biochem Behav. 2014 Sep;124:1-4. doi: 10.1016/j.pbb.2014.05.008. Epub 2014 May 15.
RU 24969 is a widely used, but non-selective, 5-HT1B/1A agonist that decreases fluid consumption and increases forward locomotion. The mechanism underlying these behavioural responses is not, however, well understood. Accordingly, effects of the selective 5-HT1A and 5-HT1B antagonists, WAY 100635, and GR 127935, respectively, on these two responses to RU 24969 were determined. RU 24969 (0.03-3.0mg/kg, s.c.) dose-dependently decreased water consumption in water deprived rats. This effect was attenuated by GR 127935 (3.0mg/kg), but not by WAY 100635 (1.0mg/kg). RU 24969 (0.3-3.0mg/kg) dose-dependently increased forward locomotion but a higher dose was required to produce this response than the adipsic response. The increased locomotor response was attenuated by WAY 100635 (1.0mg/kg), but not GR 127935 (3.0mg/kg). These results suggest that RU 24969-induced adipsia is mediated by 5-HT1B mechanisms, while RU 24969-induced hyperlocomotion is mediated by 5-HT1A mechanisms.
RU 24969是一种广泛使用但无选择性的5-HT1B/1A激动剂，它能减少液体消耗并增加向前运动。然而，这些行为反应背后的机制尚未得到很好的理解。因此，分别测定了选择性5-HT1A拮抗剂WAY 100635和5-HT1B拮抗剂GR 127935对RU 24969这两种反应的影响。RU 24969（0.03 - 3.0mg/kg，皮下注射）剂量依赖性地降低了缺水大鼠的水消耗。这种作用被GR 127935（3.0mg/kg）减弱，但未被WAY 100635（1.0mg/kg）减弱。RU 24969（0.3 - 3.0mg/kg）剂量依赖性地增加向前运动，但产生这种反应所需的剂量高于厌食反应所需的剂量。增加的运动反应被WAY 100635（1.0mg/kg）减弱，但未被GR 127935（3.0mg/kg）减弱。这些结果表明，RU 24969诱导的厌食是由5-HT1B机制介导的，而RU 24969诱导的运动亢进是由5-HT1A机制介导的。
