Centenary Institute of Cancer Medicine and Cell Biology, Sydney, NSW, Australia.
Expert Rev Gastroenterol Hepatol. 2014 Aug;8(6):633-47. doi: 10.1586/17474124.2014.909725. Epub 2014 May 20.
Enormous progress has been made in the understanding of the hepatitis C virus and the development of novel therapeutic agents since the identification of the virus 25 years ago. From initial interferon monotherapy providing only 6% viral clearance rate in the 1980s, pharmacotherapeutics has now entered an exciting new era with direct-acting antiviral agents demonstrating viral clearance rates of more than 70%. We are now at the beginning of an era where combinations of direct-acting antiviral agents may pave the way for interferon-free regimens, even improving the viral clearance rate to near 100%.
自 25 年前发现丙型肝炎病毒以来，人们对该病毒的认识以及新型治疗药物的研发都取得了巨大的进展。从 20 世纪 80 年代初始的干扰素单一疗法，清除病毒的有效率仅为 6%，到现在，直接作用抗病毒药物的出现已经将治疗带入了一个激动人心的新时代，其病毒清除率超过 70%。我们现在正处于一个新纪元的开端，直接作用抗病毒药物的联合应用可能为无干扰素治疗方案铺平道路，甚至使病毒清除率接近 100%。
