Department of Surgery, Duke University Medical Center and Duke Cancer Institute, Durham, North Carolina.
J Surg Oncol. 2014 Jul;110(1):58-61. doi: 10.1002/jso.23622. Epub 2014 May 21.
Breast conserving therapy with radiation is now firmly established as an effective treatment option for early stage disease, and has been thought for decades to yield equivalent survival outcomes to mastectomy. However, recently published observational studies as well as meta-analyses suggest not only a locoregional, but possibly a systemic benefit to BCT. Choice of surgery and radiation is only one of numerous factors impacting survival following surgery for early stage breast cancer; competing comorbidities and risk of treatment related side effects from radiotherapy must also be considered in order to make optimal treatment recommendations.
保乳放疗现已被确立为早期疾病的有效治疗选择，几十年来，人们一直认为它的生存结果与乳房切除术相当。然而，最近发表的观察性研究和荟萃分析不仅表明保乳放疗有局部和区域获益，而且可能有全身获益。选择手术和放疗只是影响早期乳腺癌手术后生存的众多因素之一；为了提出最佳治疗建议，还必须考虑到其他并存疾病和放疗相关副作用的治疗风险。
