Carpenter Todd J, Kann Benjamin, Buckstein Michael H, Ko Eric C, Bakst Richard L, Misiukiewicz Krzysztof J, Posner Marshall R, Genden Eric M, Gupta Vishal
Department of Radiation Oncology, Mount Sinai Medical Center, New York, NY, USA.
Department of Medicine, Mount Sinai Medical Center, New York, NY, USA.
Ann Otol Rhinol Laryngol. 2014 Nov;123(11):791-7. doi: 10.1177/0003489414535560. Epub 2014 May 20.
Overall treatment package time (from surgery to radiotherapy [RT] completion) > 100 days can portend poor outcomes in head and neck cancer. Faster postoperative recovery seen with transoral robotic surgery may decrease treatment duration and toxicity for adjuvant RT and chemoradiation.
We retrospectively reviewed all patients treated with transoral robotic surgery (n = 124) and adjuvant RT and chemoradiation (n = 33) at our institution for head and neck cancer from April 2007 to December 2011 to determine treatment duration, acute toxicity, and long-term percutaneous gastric tube rates.
The median overall treatment time was 86 days and from surgery to RT start was 41 days; median RT duration was 44 days. No wound breakdown or infection occurred during or after RT. Two-year actuarial locoregional control, distant metastasis-free survival, and overall survival rates were 93%, 96%, and 97%, respectively.
Adjuvant RT after transoral robotic surgery for head and neck cancer can be completed safely and in a timely fashion. Longer follow-up and a larger cohort will be needed to determine if this regimen is more effective than traditional surgery followed by adjuvant RT.
总体治疗疗程（从手术至放疗结束）超过100天可能预示着头颈癌预后不良。经口机器人手术术后恢复更快，可能会缩短辅助放疗及放化疗的治疗时长并降低毒性。
我们回顾性分析了2007年4月至2011年12月在我院接受经口机器人手术（n = 124）及辅助放疗和放化疗（n = 33）的所有头颈癌患者，以确定治疗时长、急性毒性及长期经皮胃管置入率。
总体治疗时间中位数为86天，从手术至放疗开始的时间为41天；放疗持续时间中位数为44天。放疗期间及放疗后未发生伤口裂开或感染。两年精算局部区域控制率、无远处转移生存率及总生存率分别为93%、96%和97%。
头颈癌经口机器人手术后的辅助放疗能够安全、及时地完成。需要更长时间的随访及更大样本量的队列研究来确定该治疗方案是否比传统手术加辅助放疗更有效。
