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Shengmai Injection Suppresses Angiotensin II-Induced Cardiomyocyte Hypertrophy and Apoptosis Activation of the AMPK Signaling Pathway Through Energy-Dependent Mechanisms.生脉注射液通过能量依赖机制抑制血管紧张素 II 诱导的心肌细胞肥大和凋亡以及 AMPK 信号通路的激活。
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Left Ventricular Transmural Gradient in Mitochondrial Respiration Is Associated with Increased Sub-Endocardium Nitric Oxide and Reactive Oxygen Species Productions.线粒体呼吸中的左心室跨壁梯度与心内膜下一氧化氮和活性氧生成增加有关。
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1
Transmural heterogeneity of cellular level power output is reduced in human heart failure.在人类心力衰竭中，细胞水平功率输出的跨壁异质性降低。
J Mol Cell Cardiol. 2014 Jul;72:1-8. doi: 10.1016/j.yjmcc.2014.02.008. Epub 2014 Feb 20.
2
Matrix revisited: mechanisms linking energy substrate metabolism to the function of the heart.重新审视基质：能量底物代谢与心脏功能相关的机制。
Circ Res. 2014 Feb 14;114(4):717-29. doi: 10.1161/CIRCRESAHA.114.301863.
3
Altered ventricular torsion and transmural patterns of myocyte relaxation precede heart failure in aging F344 rats.衰老 F344 大鼠心力衰竭前，心室扭转和心肌细胞松弛的跨壁模式发生改变。
Am J Physiol Heart Circ Physiol. 2013 Sep 1;305(5):H676-86. doi: 10.1152/ajpheart.00797.2012. Epub 2013 Jun 21.
4
Subendocardial increase in reactive oxygen species production affects regional contractile function in ischemic heart failure.活性氧产物在心肌内膜下增加会影响缺血性心力衰竭的局部收缩功能。
Antioxid Redox Signal. 2013 Mar 20;18(9):1009-20. doi: 10.1089/ars.2012.4534. Epub 2012 Oct 26.
5
Pressure overload-induced mild cardiac hypertrophy reduces left ventricular transmural differences in mitochondrial respiratory chain activity and increases oxidative stress.压力超负荷诱导的轻度心脏肥大可降低左心室跨壁线粒体呼吸链活性差异并增加氧化应激。
Front Physiol. 2012 Aug 28;3:332. doi: 10.3389/fphys.2012.00332. eCollection 2012.
6
Transmural heterogeneity of myofilament function and sarcomeric protein phosphorylation in remodeled myocardium of pigs with a recent myocardial infarction.近期心肌梗死猪重塑心肌中肌丝功能和肌节蛋白磷酸化的透壁异质性
Front Physiol. 2011 Nov 24;2:83. doi: 10.3389/fphys.2011.00083. eCollection 2011.
7
Torsion of the human left ventricle: experimental analysis and computational modeling.人类左心室扭转：实验分析与计算建模。
Prog Biophys Mol Biol. 2011 Oct;107(1):112-21. doi: 10.1016/j.pbiomolbio.2011.07.008. Epub 2011 Jul 23.
8
Transmural heterogeneity and remodeling of ventricular excitation-contraction coupling in human heart failure.人心力衰竭中心室兴奋-收缩偶联的跨壁异质性和重构。
Circulation. 2011 May 3;123(17):1881-90. doi: 10.1161/CIRCULATIONAHA.110.989707. Epub 2011 Apr 18.
9
Cardiac mitochondria in heart failure: normal cardiolipin profile and increased threonine phosphorylation of complex IV.心力衰竭中的心脏线粒体：正常的心磷脂谱及复合物IV的苏氨酸磷酸化增加
Biochim Biophys Acta. 2011 Nov;1807(11):1373-82. doi: 10.1016/j.bbabio.2011.02.003. Epub 2011 Feb 12.
10
In-treatment midwall and endocardial fractional shortening predict cardiovascular outcome in hypertensive patients with preserved baseline systolic ventricular function: the Losartan Intervention For Endpoint reduction study.在基线收缩期心室功能正常的高血压患者中，治疗中的中层和心内膜节段缩短率可预测心血管结局：氯沙坦干预终点降低研究。
J Hypertens. 2010 Jul;28(7):1541-6. doi: 10.1097/HJH.0b013e328339f943.

Myocardial hypertrophy reduces transmural variation in mitochondrial function.

作者信息

Haynes Premi, Campbell Kenneth S

机构信息

Department of Physiology, Center for Muscle Biology, University of Kentucky Lexington, KY, USA.

出版信息

Front Physiol. 2014 May 7;5:178. doi: 10.3389/fphys.2014.00178. eCollection 2014.

DOI:10.3389/fphys.2014.00178
PMID:24847280
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4019838/
Abstract
摘要